Welcome to the website of Dr Hanns Lochmüller’s research group in Ottawa, Canada. These pages are maintained by group members to provide an overview of our research and clinical activities.
We focus on scientific, genetic and clinical research into rare neuromuscular disorders and clinical care for patients with these conditions. We aim to understand why small variations in the human genome lead to these frequently disabling, sometimes lethal, and rarely treatable conditions affecting the musculature and nervous system. Our group has a bench-to-bedside translational approach, from identifying underlying genetic defects in patients using deep phenotyping and next-generation sequencing, through unravelling molecular pathways in cell and animal models, to testing new targeted therapies in clinical trials.
Hanns is affiliated with the CHEO Research Institute’s Molecular Biomedicine Program and the CHEO Department of Pediatrics, as well as the Department of Medicine, Division of Neurology of The Ottawa Hospital and the Department of Cellular and Molecular Medicine and the Brain and Mind Research Institute at the University of Ottawa. His group members work across various of these affiliations and he has close collaborations with many other research groups across the world.