Research Associate, CHEO Research InstituteEmail Sally
Sally completed her PhD in the Mitochondrial Research Group in Newcastle, UK in 2012 under the supervision of Professors Doug Turnbull and Hanns Lochmüller. Her thesis examined the presence of mitochondrial DNA deletions in muscle stem cells (satellite cells) in patients with mitochondrial myopathies.
Following her PhD, she moved across the Atlantic to Montreal to begin what would be a 4-year post-doctoral position with Professors Tanja Taivassalo and Russell Hepple, at first at McGill University and then at the McGill University Health Centre. Initially she worked on projects examining the role of mitochondria in clinical conditions (e.g COPD) and ageing, and later moved on to explore the role of neuromuscular junction (NMJ) stability in ageing. In 2016 she returned to the UK and Newcastle to work with Professor Lochmüller on a project to test novel treatments for patients with congenital myasthenic syndromes (disorders of the NMJ).
Sally is extremely excited to have returned to Canada and to be helping Professor Lochmüller set up his lab in Ottawa.
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McMacken, GM, Spendiff, S, Whittaker, RG, O'Connor, E, Howarth, RM, Boczonadi, V et al.. Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndrome. Hum. Mol. Genet. 2019.28 (14)2339-2351 PMID:31220253
Sonjak, V, Jacob, KJ, Spendiff, S, Vuda, M, Perez, A, Miguez, K et al.. Reduced Mitochondrial Content, Elevated ROS, and Modulation by Denervation in Skeletal Muscle of Pre-frail/Frail Elderly Women. J. Gerontol. A Biol. Sci. Med. Sci. 2019. PMID:30855073
Cipriani, S, Phan, V, Médard, JJ, Horvath, R, Lochmüller, H, Chrast, R et al.. Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C. Int J Mol Sci. 2018.19 (12) PMID:30562927
Phan, V, Cox, D, Cipriani, S, Spendiff, S, Buchkremer, S, O'Connor, E et al.. SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. Neurobiol. Dis. 2019.124 218-229 PMID:30468864
Silveira, C, Brunton, E, Spendiff, S, Nazarpour, K. Positioning the Nerve Cuff Distally on the Sciatic Nerve Improves the Classification of Ankle-Movement Proprioceptive ENG Signals. Conf Proc IEEE Eng Med Biol Soc. 2018.2018 2430-2433 PMID:30440898
Issop, Y, Hathazi, D, Khan, MM, Rudolf, R, Weis, J, Spendiff, S et al.. GFPT1 deficiency in muscle leads to myasthenia and myopathy in mice. Hum. Mol. Genet. 2018.27 (18)3218-3232 PMID:29905857
Silveira, C, Brunton, E, Spendiff, S, Nazarpour, K. Influence of nerve cuff channel count and implantation site on the separability of afferent ENG. J Neural Eng. 2018.15 (4)046004 PMID:29629880
O'Connor, E, Töpf, A, Zahedi, RP, Spendiff, S, Cox, D, Roos, A et al.. Clinical and research strategies for limb-girdle congenital myasthenic syndromes. Ann. N. Y. Acad. Sci. 2018.1412 (1)102-112 PMID:29315608
McMacken, G, Abicht, A, Evangelista, T, Spendiff, S, Lochmüller, H. The Increasing Genetic and Phenotypical Diversity of Congenital Myasthenic Syndromes. Neuropediatrics. 2017.48 (4)294-308 PMID:28505670
Spendiff, S, Vuda, M, Gouspillou, G, Aare, S, Perez, A, Morais, JA et al.. Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J. Physiol. (Lond.). 2016.594 (24)7361-7379 PMID:27619626See more on PubMed