Research Associate, CHEO Research InstituteEmail Sally
Sally completed her PhD in the Mitochondrial Research Group in Newcastle, UK in 2012 under the supervision of Professors Doug Turnbull and Hanns Lochmüller. Her thesis examined the presence of mitochondrial DNA deletions in muscle stem cells (satellite cells) in patients with mitochondrial myopathies.
Following her PhD, she moved across the Atlantic to Montreal to begin what would be a 4-year post-doctoral position with Professors Tanja Taivassalo and Russell Hepple, at first at McGill University and then at the McGill University Health Centre. Initially she worked on projects examining the role of mitochondria in clinical conditions (e.g COPD) and ageing, and later moved on to explore the role of neuromuscular junction (NMJ) stability in ageing. In 2016 she returned to the UK and Newcastle to work with Professor Lochmüller on a project to test novel treatments for patients with congenital myasthenic syndromes (disorders of the NMJ).
Sally is extremely excited to have returned to Canada and to be helping Professor Lochmüller set up his lab in Ottawa.
Read more about Sally
Manta, A, Spendiff, S, Lochmüller, H, Thompson, R. Targeted Therapies for Metabolic Myopathies Related to Glycogen Storage and Lipid Metabolism: a Systematic Review and Steps Towards a 'Treatabolome'. J Neuromuscul Dis. 2021. PMID:33720849
Jacob, KJ, Sonjak, V, Spendiff, S, Hepple, RT, Chevalier, S, Perez, A et al.. Mitochondrial Content, but Not Function, Is Altered With a Multimodal Resistance Training Protocol and Adequate Protein Intake in Leucine-Supplemented Pre/Frail Women. Front Nutr. 2020.7 619216 PMID:33553232
Spendiff, S, Howarth, R, McMacken, G, Davey, T, Quinlan, K, O'Connor, E et al.. Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of Congenital Myasthenic Syndrome. Front Mol Neurosci. 2020.13 594220 PMID:33390901
Thompson, R, Spendiff, S, Roos, A, Bourque, PR, Warman Chardon, J, Kirschner, J et al.. Advances in the diagnosis of inherited neuromuscular diseases and implications for therapy development. Lancet Neurol. 2020.19 (6)522-532 PMID:32470424
O'Connor, E, Cairns, G, Spendiff, S, Burns, D, Hettwer, S, Mäder, A et al.. Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish. Cells. 2019.8 (8) PMID:31394789
Sonjak, V, Jacob, K, Morais, JA, Rivera-Zengotita, M, Spendiff, S, Spake, C et al.. Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women. J Physiol. 2019.597 (19)5009-5023 PMID:31368533
McMacken, GM, Spendiff, S, Whittaker, RG, O'Connor, E, Howarth, RM, Boczonadi, V et al.. Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndrome. Hum Mol Genet. 2019.28 (14)2339-2351 PMID:31220253
Sonjak, V, Jacob, KJ, Spendiff, S, Vuda, M, Perez, A, Miguez, K et al.. Reduced Mitochondrial Content, Elevated Reactive Oxygen Species, and Modulation by Denervation in Skeletal Muscle of Prefrail or Frail Elderly Women. J Gerontol A Biol Sci Med Sci. 2019.74 (12)1887-1895 PMID:30855073
Cipriani, S, Phan, V, Médard, JJ, Horvath, R, Lochmüller, H, Chrast, R et al.. Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C. Int J Mol Sci. 2018.19 (12) PMID:30562927
Phan, V, Cox, D, Cipriani, S, Spendiff, S, Buchkremer, S, O'Connor, E et al.. SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. Neurobiol Dis. 2019.124 218-229 PMID:30468864See more on PubMed