News

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May 2022 Issue of the Journal of Neuromuscular Diseases Available Online

The Lochmüller Lab is pleased to share that the the Journal of Neuromuscular Diseases has published its third issue of 2022! In Volume 9, Issue 3 of the JND almost half of all the articles are open access, with this latest issue containing a range of reviews and research papers.
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CHEO Registers Tenth Patient in AMO Reach CDM Clinical Trial

The Lochmüller Lab is excited to share that as of March 14, 2022 our site at the Children’s Hospital of Eastern Ontario (CHEO) has registered its tenth participant for AMO’s Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Tideglusib Versus Placebo for the Treatment of Children and Adolescents with...
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Canadian Neuromuscular Disease Registry Launches New Congenital Myasthenic Syndrome Registry

We’re delighted to announce that a new registry for patients with congenital myasthenic syndrome (CMS) has just been launched within the Canadian Neuromuscular Disease Registry (CNDR).  This new initiative is led by Dr. Hanns Lochmüller as an academic study as a part of Dr. Lochmüller’s CIHR foundation grant for CMS research, and supported by the NMD4C....
Lochmuller Lab at the Rideau Canal, group picture.

Lochmüller Lab Visits World’s Longest Skating Rink

This February the Lochmüller Lab took a break from the research benches at the CHEO RI to visit the Rideau Canal Skateway. A UNESCO world heritage site, the Rideau Canal Skateway is a 7.8 km long skating path that winds its way through downtown Ottawa and provides a beautiful way...
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January 2022 Issue of the Journal of Neuromuscular Diseases Available Online

The Lochmüller Lab is pleased to share that the the Journal of Neuromuscular Diseases has published its first issue of 2022! In Volume 9, Issue 1 of the JND almost half of all the articles are open access, with this latest issue containing a range of reviews and research papers....
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Happy Holidays from the Lochmüller Lab

The Lochmüller Lab would like to wish everyone a happy holidays full of good cheer! The lab members have been hard at work over the last week to spread holiday cheer, and have found creative ways to get into the festive spirit.. Lab Tree Ornaments The CHEO RI Christmas tree...
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Jarred Lau Successful in Master’s Defense

The Lochmüller Lab would like to congratulate Master's student Jarred Lau on successfully defending his thesis this month! Jarred’s thesis looked at unsolved patients with congenital myasthenic syndromes (CMS), a rare inherited neuromuscular disease caused by disrupted signal transmission at the neuromuscular junction (NMJ). Analysis of these patients’ exome data...
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Dr. Hanns Lochmüller Receives the Dr. George Karpati Award for Researcher of the Year

Dr. Hanns Lochmüller is the recipient of Muscular Dystrophy Canada's Dr. George Karpati Award for Researcher of the Year! This prestigious award is presented annually to an exemplary neuromuscular clinician or researcher who has made a significant contribution to neuromuscular research, or the advancement of care of people with neuromuscular...
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Dr. Hanns Lochmüller, NMD4C and MDC named co-investigators on two CIHR grants awarded for research into oculopharyngeal muscular dystrophy – led by Dr C Gagnon – and into the Indirect Socio-Economic Burden of Inherited Neuromuscular Diseases – led by Dr J Warman

The Lochmüller Lab is happy to share that project applications ‘A comprehensive study of the natural history of OPMD: An essential step towards clinical trial readiness and evidence-based interventions’ and ‘BIND Study: Assessing the Indirect Socio-Economic Burden of Inherited Neuromuscular Diseases’ have been awarded Canadian Institute of Health Research (CIHR)...
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Lochmüller Lab Welcomes New Students

Our lab is growing! We are excited to introduce two new students who have joined the Lochmüller Lab this fall.   Kelly Ho Kelly has joined as a Master’s student in Cellular and Molecular Medicine to study the effects of forskolin and salbutamol in a mouse model for congenital myasthenic...
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Latest Issue of the Journal of Neuromuscular Diseases Now Available – July 2021

The Journal of Neuromuscular Diseases (JND) has announced the publication of a new issue of the journal!     Volume 8, Issue 4 of the JND contains a record number 30 items comprised of  research articles, meeting reports and reviews, many of them open access, and is now available online.   The JND is dedicated to providing an...
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Meet the Lochmüller Lab Clinical Team

Neuromuscular Clinic for adult patients at The Ottawa Hospital (TOH) Civic Campus As part of the team led by Dr. Jodi Warman Chardon, Hanns sees neuromuscular patients in clinic at the Ottawa Neuromuscular Centre, located at the Civic Campus of The Ottawa Hospital.  This newly opened state-of-the-art centre is a...
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Special issue of the Journal of Neuromuscular Diseases is devoted to the Treatabolome, designed to shorten diagnosis-to-treatment time for patients with rare diseases

In 2019, as part of the European Solve-RD project, Hanns Lochmüller, Gisèle Bonne and Rachel Thompson launched the Treatabolome, an initiative designed to extract details of effective treatments for rare diseases from the scientific literature and make them accessible through an online database that aims to allow patients to receive...
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ProDGNE: Research Project to Develop an Innovative Therapeutic Compound to Treat GNE Myopathy

The Lochmüller Lab is proud to share its involvement in ProDGNE , a three-year transnational pre-clinical research project which aims to develop an innovative therapeutic compound to treat GNE Myopathy (GNEM), an ultra rare muscle disease affecting young adults. ProDGNE represents a unique collaboration among patients and European and Canadian...
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Meet the lab’s two new members

Our lab is growing! We are excited to introduce two new members who have joined the Lochmüller lab this winter. Daniel O'Neil Daniel holds a BSc in Biochemistry from the University of Ottawa. During his undergraduate studies, he worked with Dr. Alexandre Blais’s laboratory where he studied the role of...
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New publication: Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of CMS

Our new paper, spearheaded by our lab manager Dr Spendiff, is now available online at Frontiers Molecular Neuroscience. This project is a product of an ongoing collaboration with the Zürich-based biotech company Neurotune AG. Neurotune AG’s drug NT1654 has shown efficacy in a number of animal models with muscle weakness,...