Andreas Roos
Adjunct Professor, University of Ottawa
Scientific Officer, Department of Neuropediatrics, University Hospital Essen
Email AndreasAndreas completed his PhD in 2009 with Professor Jan Senderek in the Neurogenetics group of the Institute of Human Genetics of RWTH-Aachen University in Germany, where his thesis focused on the elucidation of molecular and biochemical mechanisms in autosomal recessive Charcot-Marie-Tooth neuropathies. Following a postdoc in the Institute of Molecular Biology and Medical Biochemistry at the University of Saarland, he became a junior group leader at the Institute of Neuropathology at RWTH-Aachen University. Subsequently, he took on the role of group lead of the Tissue Omics group at the Leibniz Institute of Analytical Science (ISAS) in Dortmund, focusing on applied proteomics toward a better understanding of the molecular genesis of neuromuscular diseases. In 2015 he moved to Newcastle upon Tyne (UK) as Scientific Officer in the John Walton Muscular Dystrophy Research Centre under Professor Hanns Lochmüller. After moving to Essen in Germany in 2018 to become Scientific Officer in the University Hospital Essen’s Department of Neuropediatrics, together with Prof. Ulrike Schara he was awarded a 2.9M Euro grant from the European Regional Development Fund for NMD-GPS, a major interdisciplinary multi-omics project aiming to improve the diagnostic management of patients with neuromuscular diseases as well as to group these diseases according to their underlying pathomechanisms.
In 2019 Andreas was awarded an adjunct professorship at the University of Ottawa, where he will be an external/visiting member of the Lochmüller Lab team, teaching applied proteomics in the context of neuromuscular diseases, co-supervising students and continuing his many close scientific collaborations with the group.
In 2023, Andreas received the World Muscle Society’s President’s Prize for Emerging Myologist of the Year.
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Recent publications
Langer, HT, Gilmore, NK, Hayden, CMT, Roux, J, Bariohay, B, Rouquet, T et al.. Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans. Cell Rep Med. 2026.7 (3)102665 PMID:41850248
Pauper, M, Kölbel, H, Karakesisoglou, I, Schänzer, A, Böhm, J, Thompson, R et al.. A muscular dystrophy associated with bi-allelic LEMD2 variants: Expanding the genotype of nuclear envelopathies. Brain Pathol. 2026. e70082 PMID:41776713
Bertino, F, Zanin Venturini, DI, Grasso, E, Kopecka, J, Salio, C, Gnutti, B et al.. Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy. Commun Biol. 2026.9 (1) PMID:41691085
Daya, NM, Schänzer, A, Hentschel, A, Kienitz, MC, Sellung, D, Suedkamp, N et al.. Unveiling FLNC variants: iPSC-derived myogenic cells as a model to study disease mechanisms. Skelet Muscle. 2026. PMID:41680819
Krämer-Best, HH, Reis, MC, Hentschel, A, Weiß, M, Schaiter, A, Böhm, KD et al.. Myopathy With Exercise-Induced Intolerance due to Novel Biallelic Variants in OBSCN-A Clinical, Morphological and Molecular Analysis. Neuropathol Appl Neurobiol. 2026.52 (1)e70065 PMID:41645489
Kleefeld, F, Schroeter, CB, Abdennebi, D, Dobelmann, V, Walli, S, Roos, A et al.. Proteomic profiles in inclusion body myositis and polymyositis with mitochondrial pathology. Acta Neuropathol Commun. 2026.14 (1) PMID:41639907
Mroczek, M, Preusse, C, Hentschel, A, Chrościńska-Krawczyk, M, Bielak, M, Sobolewska, A et al.. Exploring molecular signatures in PURA syndrome using muscle proteomics and serum biomarkers. J Neurol. 2026.273 (2)94 PMID:41575592
van As, D, Claeys, T, Salz, R, Haver, DV, Dufour, S, Deelen, AV et al.. Large-scale proteomics profiling of peripheral blood of DM1 patients identifies biomarkers for disease severity and functional capacity. J Neuromuscul Dis. 2026. 22143602251410443 PMID:41544176
Leo, M, Schmitt, LI, Liebig, KC, Hezel, S, Neuhoff, S, Roos, A et al.. Choosing the optimal mouse model for the study of late-onset spinal muscular atrophy: Why the 4-copy SMN2 model offers ideal translational relevance. J Neuromuscul Dis. 2026. 22143602251405151 PMID:41540953
Kilicarslan, OA, Gangfuß, A, Hentschel, A, Kölbel, H, Muhmann, D, Töpf, A et al.. A Homozygous CPSF1 Variant Causes Congenital Cataract, Intellectual Disability and Hyperphagia. Clin Genet. 2026. PMID:41498167
Aksel Kilicarslan, O, Gangfuß, A, Kölbel, H, Muhmann, D, Polavarapu, K, Thompson, R et al.. Combined Histological and Proteomic Analysis Reveals Muscle Denervation in KMT5B-Related Neurodevelopmental Disorder: A Case Report. J Clin Med. 2025.14 (24) PMID:41464539
Ruffer, N, Pinal-Fernandez, I, Preusse, C, Mammen, AL, Holzer, MT, Kleefeld, F et al.. Vasculitic fasciitis characterizes a distinct subset of vasculitic myopathy with interferon-gamma signature. Acta Neuropathol. 2025.151 (1)2 PMID:41441888
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