Andreas Roos
Adjunct Professor, University of Ottawa
Scientific Officer, Department of Neuropediatrics, University Hospital Essen
Email AndreasAndreas completed his PhD in 2009 with Professor Jan Senderek in the Neurogenetics group of the Institute of Human Genetics of RWTH-Aachen University in Germany, where his thesis focused on the elucidation of molecular and biochemical mechanisms in autosomal recessive Charcot-Marie-Tooth neuropathies. Following a postdoc in the Institute of Molecular Biology and Medical Biochemistry at the University of Saarland, he became a junior group leader at the Institute of Neuropathology at RWTH-Aachen University. Subsequently, he took on the role of group lead of the Tissue Omics group at the Leibniz Institute of Analytical Science (ISAS) in Dortmund, focusing on applied proteomics toward a better understanding of the molecular genesis of neuromuscular diseases. In 2015 he moved to Newcastle upon Tyne (UK) as Scientific Officer in the John Walton Muscular Dystrophy Research Centre under Professor Hanns Lochmüller. After moving to Essen in Germany in 2018 to become Scientific Officer in the University Hospital Essen’s Department of Neuropediatrics, together with Prof. Ulrike Schara he was awarded a 2.9M Euro grant from the European Regional Development Fund for NMD-GPS, a major interdisciplinary multi-omics project aiming to improve the diagnostic management of patients with neuromuscular diseases as well as to group these diseases according to their underlying pathomechanisms.
In 2019 Andreas was awarded an adjunct professorship at the University of Ottawa, where he will be an external/visiting member of the Lochmüller Lab team, teaching applied proteomics in the context of neuromuscular diseases, co-supervising students and continuing his many close scientific collaborations with the group.
In 2023, Andreas received the World Muscle Society’s President’s Prize for Emerging Myologist of the Year.
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Recent publications
Aksel Kilicarslan, O, Gangfuß, A, Kölbel, H, Muhmann, D, Polavarapu, K, Thompson, R et al.. Combined Histological and Proteomic Analysis Reveals Muscle Denervation in KMT5B-Related Neurodevelopmental Disorder: A Case Report. J Clin Med. 2025.14 (24) PMID:41464539
Ruffer, N, Pinal-Fernandez, I, Preusse, C, Mammen, AL, Holzer, MT, Kleefeld, F et al.. Vasculitic fasciitis characterizes a distinct subset of vasculitic myopathy with interferon-gamma signature. Acta Neuropathol. 2025.151 (1)2 PMID:41441888
Salmanian, S, Schmitt, LI, Liebig, KC, Hezel, S, Roos, A, Schara-Schmidt, U et al.. Targeting Astrocytic Connexin 43 Mitigates Glutamate-Driven Motor Neuron Stress in Late-Onset Spinal Muscular Atrophy. Cells. 2025.14 (23) PMID:41369341
Merlet, AN, Lacène, E, Nelson, I, Brochier, G, Labasse, C, Chanut, A et al.. Clinical, morphological, and molecular characterization of patients with X-linked myopathy with excessive autophagy (XMEA). J Neuropathol Exp Neurol. 2025. PMID:41307411
Labella, B, Brochier, G, Beuvin, M, Lacene, E, Chanut, A, Madelaine, A et al.. Unveiling MYH2-related myopathy: Histological-genetic insights from a case series and systematic review. J Neuromuscul Dis. 2025. 22143602251393910 PMID:41252304
Dohrn, MF, Pareyson, D, Pisciotta, C, Kölbel, H, Roos, A, Fabrizi, GM et al.. Charcot-Marie-Tooth-SORD: insights into pathology and pathophysiology from a human nerve biopsy series. Brain. 2025. PMID:41206017
Zillich, L, Gasparotto, M, Rossetti, AC, Fechtner, O, Maillard, C, Hoffrichter, A et al.. Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids. Nat Commun. 2025.16 (1)9091 PMID:41083500
Dafsari, HS, Deneubourg, C, Singh, K, Maroofian, R, Suprenant, Z, Kho, AL et al.. Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism. Ann Neurol. 2025.98 (5)932-950 PMID:41053928
Stascheit, F, Roos, A, Schroeter, CB, Thomas, JK, Hahn, K, Preßler, H et al.. Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy. Acta Neuropathol. 2025.150 (1)32 PMID:40971018
Südkamp, N, Heinen-Weiler, J, Rohm, M, Zaik, M, Daya, N, Güttsches, AK et al.. Age, muscle, and gender specific characterization of muscle degeneration in a mouse model of calpainopathy. Sci Rep. 2025.15 (1)32507 PMID:40940393
Holland, SH, Carmona-Martinez, R, O'Neil, D, Ho, K, O'Connor, K, Azuma, Y et al.. Galactose treatment rescues neuromuscular junction transmission in glutamine-fructose-6-phosphate transaminase 1 (Gfpt1) deficient mice. Hum Mol Genet. 2025.34 (21)1765-1779 PMID:40879313
Paul, L, Schänzer, A, Depienne, C, Hentschel, A, Kohlschmidt, N, Schara-Schmidt, U et al.. Lessons learned from a muscle study in nail-patella syndrome. Orphanet J Rare Dis. 2025.20 (1)384 PMID:40721798
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