Andreas Roos
Adjunct Professor, University of Ottawa
Scientific Officer, Department of Neuropediatrics, University Hospital Essen
Email AndreasAndreas completed his PhD in 2009 with Professor Jan Senderek in the Neurogenetics group of the Institute of Human Genetics of RWTH-Aachen University in Germany, where his thesis focused on the elucidation of molecular and biochemical mechanisms in autosomal recessive Charcot-Marie-Tooth neuropathies. Following a postdoc in the Institute of Molecular Biology and Medical Biochemistry at the University of Saarland, he became a junior group leader at the Institute of Neuropathology at RWTH-Aachen University. Subsequently, he took on the role of group lead of the Tissue Omics group at the Leibniz Institute of Analytical Science (ISAS) in Dortmund, focusing on applied proteomics toward a better understanding of the molecular genesis of neuromuscular diseases. In 2015 he moved to Newcastle upon Tyne (UK) as Scientific Officer in the John Walton Muscular Dystrophy Research Centre under Professor Hanns Lochmüller. After moving to Essen in Germany in 2018 to become Scientific Officer in the University Hospital Essen’s Department of Neuropediatrics, together with Prof. Ulrike Schara he was awarded a 2.9M Euro grant from the European Regional Development Fund for NMD-GPS, a major interdisciplinary multi-omics project aiming to improve the diagnostic management of patients with neuromuscular diseases as well as to group these diseases according to their underlying pathomechanisms.
In 2019 Andreas was awarded an adjunct professorship at the University of Ottawa, where he will be an external/visiting member of the Lochmüller Lab team, teaching applied proteomics in the context of neuromuscular diseases, co-supervising students and continuing his many close scientific collaborations with the group.
In 2023, Andreas received the World Muscle Society’s President’s Prize for Emerging Myologist of the Year.
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Recent publications
Merlet, AN, Lacène, E, Nelson, I, Brochier, G, Labasse, C, Chanut, A et al.. Clinical, morphological, and molecular characterization of patients with X-linked myopathy with excessive autophagy (XMEA). J Neuropathol Exp Neurol. 2025. PMID:41307411
Labella, B, Brochier, G, Beuvin, M, Lacene, E, Chanut, A, Madelaine, A et al.. Unveiling MYH2-related myopathy: Histological-genetic insights from a case series and systematic review. J Neuromuscul Dis. 2025. 22143602251393910 PMID:41252304
Dohrn, MF, Pareyson, D, Pisciotta, C, Kölbel, H, Roos, A, Fabrizi, GM et al.. Charcot-Marie-Tooth-SORD: insights into pathology and pathophysiology from a human nerve biopsy series. Brain. 2025. PMID:41206017
Zillich, L, Gasparotto, M, Rossetti, AC, Fechtner, O, Maillard, C, Hoffrichter, A et al.. Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids. Nat Commun. 2025.16 (1)9091 PMID:41083500
Dafsari, HS, Deneubourg, C, Singh, K, Maroofian, R, Suprenant, Z, Kho, AL et al.. Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism. Ann Neurol. 2025.98 (5)932-950 PMID:41053928
Stascheit, F, Roos, A, Schroeter, CB, Thomas, JK, Hahn, K, Preßler, H et al.. Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy. Acta Neuropathol. 2025.150 (1)32 PMID:40971018
Südkamp, N, Heinen-Weiler, J, Rohm, M, Zaik, M, Daya, N, Güttsches, AK et al.. Age, muscle, and gender specific characterization of muscle degeneration in a mouse model of calpainopathy. Sci Rep. 2025.15 (1)32507 PMID:40940393
Holland, SH, Carmona-Martinez, R, O'Neil, D, Ho, K, O'Connor, K, Azuma, Y et al.. Galactose treatment rescues neuromuscular junction transmission in glutamine-fructose-6-phosphate transaminase 1 (Gfpt1) deficient mice. Hum Mol Genet. 2025.34 (21)1765-1779 PMID:40879313
Paul, L, Schänzer, A, Depienne, C, Hentschel, A, Kohlschmidt, N, Schara-Schmidt, U et al.. Lessons learned from a muscle study in nail-patella syndrome. Orphanet J Rare Dis. 2025.20 (1)384 PMID:40721798
Della Marina, A, Rink, L, Hentschel, A, Schündeln, MM, Nelke, C, Kölbel, H et al.. Co-occurrence of myositis and neuropathy after anti-CD30 therapy in a late-adolescent Hodgkin lymphoma patient. Acta Neuropathol Commun. 2025.13 (1)140 PMID:40581649
Celemín, E, Gusev, N, Domínguez, M, Havenstein, K, Berggren, P, Heide-Jørgensen, MP et al.. Evolution and Organisation of MHC II Genes in Harbour Porpoises: Insights From Long-Read Cetacean Genome Assemblies, Whole Genome Re-Sequencing and Locus-Specific Genotyping. Mol Ecol. 2025. e70006 PMID:40551555
Jacob, M, Kölbel, H, Harrer, P, Kopajtich, R, Munot, P, Achleitner, MT et al.. Deciphering DST-associated disorders: biallelic variants affecting DST-b cause a congenital myopathy. Brain. 2025. PMID:40497796
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