Andreas Roos

Adjunct Professor, University of Ottawa

Scientific Officer, Department of Neuropediatrics, University Hospital Essen

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Andreas completed his PhD in 2009 with Professor Jan Senderek in the Neurogenetics group of the Institute of Human Genetics of RWTH-Aachen University in Germany, where his thesis focused on the elucidation of molecular and biochemical mechanisms in autosomal recessive Charcot-Marie-Tooth neuropathies. Following a postdoc in the Institute of Molecular Biology and Medical Biochemistry at the University of Saarland, he became a junior group leader at the Institute of Neuropathology at RWTH-Aachen University. Subsequently, he took on the role of group lead of the Tissue Omics group at the Leibniz Institute of Analytical Science (ISAS) in Dortmund, focusing on applied proteomics toward a better understanding of the molecular genesis of neuromuscular diseases. In 2015 he moved to Newcastle upon Tyne (UK) as Scientific Officer in the John Walton Muscular Dystrophy Research Centre under Professor Hanns Lochmüller. After moving to Essen in Germany in 2018 to become Scientific Officer in the  University Hospital Essen’s Department of Neuropediatrics, together with Prof. Ulrike Schara he was awarded a 2.9M Euro grant from the European Regional Development Fund for NMD-GPS, a major interdisciplinary multi-omics project aiming to improve the diagnostic management of patients with neuromuscular diseases as well as to group these diseases according to their underlying pathomechanisms.

In 2019 Andreas was awarded an adjunct professorship at the University of Ottawa, where he will be an external/visiting member of the Lochmüller Lab team, teaching applied proteomics in the context of neuromuscular diseases, co-supervising students and continuing his many close scientific collaborations with the group.

In 2023, Andreas received the World Muscle Society’s President’s Prize for Emerging Myologist of the Year.

Dr. Andreas Roos

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Recent publications

Zillich, L, Gasparotto, M, Rossetti, AC, Fechtner, O, Maillard, C, Hoffrichter, A et al.. Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids. Nat Commun. 2025.16 (1)9091 PMID:41083500

Dafsari, HS, Deneubourg, C, Singh, K, Maroofian, R, Suprenant, Z, Kho, AL et al.. Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism. Ann Neurol. 2025. PMID:41053928

Stascheit, F, Roos, A, Schroeter, CB, Thomas, JK, Hahn, K, Preßler, H et al.. Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy. Acta Neuropathol. 2025.150 (1)32 PMID:40971018

Südkamp, N, Heinen-Weiler, J, Rohm, M, Zaik, M, Daya, N, Güttsches, AK et al.. Age, muscle, and gender specific characterization of muscle degeneration in a mouse model of calpainopathy. Sci Rep. 2025.15 (1)32507 PMID:40940393

Holland, SH, Carmona-Martinez, R, O'Neil, D, Ho, K, O'Connor, K, Azuma, Y et al.. Galactose treatment rescues neuromuscular junction transmission in glutamine-fructose-6-phosphate transaminase 1 (Gfpt1) deficient mice. Hum Mol Genet. 2025.34 (21)1765-1779 PMID:40879313

Paul, L, Schänzer, A, Depienne, C, Hentschel, A, Kohlschmidt, N, Schara-Schmidt, U et al.. Lessons learned from a muscle study in nail-patella syndrome. Orphanet J Rare Dis. 2025.20 (1)384 PMID:40721798

Della Marina, A, Rink, L, Hentschel, A, Schündeln, MM, Nelke, C, Kölbel, H et al.. Co-occurrence of myositis and neuropathy after anti-CD30 therapy in a late-adolescent Hodgkin lymphoma patient. Acta Neuropathol Commun. 2025.13 (1)140 PMID:40581649

Celemín, E, Gusev, N, Domínguez, M, Havenstein, K, Berggren, P, Heide-Jørgensen, MP et al.. Evolution and Organisation of MHC II Genes in Harbour Porpoises: Insights From Long-Read Cetacean Genome Assemblies, Whole Genome Re-Sequencing and Locus-Specific Genotyping. Mol Ecol. 2025. e70006 PMID:40551555

Jacob, M, Kölbel, H, Harrer, P, Kopajtich, R, Munot, P, Achleitner, MT et al.. Deciphering DST-associated disorders: biallelic variants affecting DST-b cause a congenital myopathy. Brain. 2025. PMID:40497796

Fogel, BL, Klopstock, T, Lynch, DR, Maltecca, F, Verma, M, Minassian, BA et al.. Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies. Ann Neurol. 2025.98 (3)448-470 PMID:40464291

Kruijt, N, Laforet, P, Vissing, J, Bhai, S, Stemmerik, MG, Kleefeld, F et al.. 276th ENMC International Workshop: recommendations on optimal diagnostic pathway and management strategy for patients with acute rhabdomyolysis worldwide. 15th-17th March 2024, Hoofddorp, The Netherlands. Neuromuscul Disord. 2025.50 105344 PMID:40220353

Kleefeld, F, Cross, E, Lagos, D, Walli, S, Schoser, B, Hentschel, A et al.. Mitochondrial damage is associated with an early immune response in inclusion body myositis. Brain. 2025.148 (9)3199-3214 PMID:40193586

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