Andreas Roos
Adjunct Professor, University of Ottawa
Scientific Officer, Department of Neuropediatrics, University Hospital Essen
Email AndreasAndreas completed his PhD in 2009 with Professor Jan Senderek in the Neurogenetics group of the Institute of Human Genetics of RWTH-Aachen University in Germany, where his thesis focused on the elucidation of molecular and biochemical mechanisms in autosomal recessive Charcot-Marie-Tooth neuropathies. Following a postdoc in the Institute of Molecular Biology and Medical Biochemistry at the University of Saarland, he became a junior group leader at the Institute of Neuropathology at RWTH-Aachen University. Subsequently, he took on the role of group lead of the Tissue Omics group at the Leibniz Institute of Analytical Science (ISAS) in Dortmund, focusing on applied proteomics toward a better understanding of the molecular genesis of neuromuscular diseases. In 2015 he moved to Newcastle upon Tyne (UK) as Scientific Officer in the John Walton Muscular Dystrophy Research Centre under Professor Hanns Lochmüller. After moving to Essen in Germany in 2018 to become Scientific Officer in the University Hospital Essen’s Department of Neuropediatrics, together with Prof. Ulrike Schara he was awarded a 2.9M Euro grant from the European Regional Development Fund for NMD-GPS, a major interdisciplinary multi-omics project aiming to improve the diagnostic management of patients with neuromuscular diseases as well as to group these diseases according to their underlying pathomechanisms.
In 2019 Andreas was awarded an adjunct professorship at the University of Ottawa, where he will be an external/visiting member of the Lochmüller Lab team, teaching applied proteomics in the context of neuromuscular diseases, co-supervising students and continuing his many close scientific collaborations with the group.
In 2023, Andreas received the World Muscle Society’s President’s Prize for Emerging Myologist of the Year.
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Recent publications
Della Marina, A, Rink, L, Hentschel, A, Schündeln, MM, Nelke, C, Kölbel, H et al.. Co-occurrence of myositis and neuropathy after anti-CD30 therapy in a late-adolescent Hodgkin lymphoma patient. Acta Neuropathol Commun. 2025.13 (1)140 PMID:40581649
Celemín, E, Gusev, N, Domínguez, M, Havenstein, K, Berggren, P, Heide-Jørgensen, MP et al.. Evolution and Organisation of MHC II Genes in Harbour Porpoises: Insights From Long-Read Cetacean Genome Assemblies, Whole Genome Re-Sequencing and Locus-Specific Genotyping. Mol Ecol. 2025. e70006 PMID:40551555
Jacob, M, Kölbel, H, Harrer, P, Kopajtich, R, Munot, P, Achleitner, MT et al.. Deciphering DST-associated disorders: biallelic variants affecting DST-b cause a congenital myopathy. Brain. 2025. PMID:40497796
Fogel, BL, Klopstock, T, Lynch, DR, Maltecca, F, Verma, M, Minassian, BA et al.. Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies. Ann Neurol. 2025. PMID:40464291
Kruijt, N, Laforet, P, Vissing, J, Bhai, S, Stemmerik, MG, Kleefeld, F et al.. 276th ENMC International Workshop: recommendations on optimal diagnostic pathway and management strategy for patients with acute rhabdomyolysis worldwide. 15th-17th March 2024, Hoofddorp, The Netherlands. Neuromuscul Disord. 2025.50 105344 PMID:40220353
Kleefeld, F, Cross, E, Lagos, D, Walli, S, Schoser, B, Hentschel, A et al.. Mitochondrial damage is associated with an early immune response in inclusion body myositis. Brain. 2025. PMID:40193586
Oeztuerk, M, Herebian, D, Dipali, K, Hentschel, A, Rademacher, N, Kraft, F et al.. Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5. Front Mol Neurosci. 2025.18 1548255 PMID:40051915
Hentschel, A, Lacene, E, Brochier, G, Boisserie, JM, Fromes, Y, Romero, NB et al.. Glycogenosis type XI, a rare association between muscle and skin manifestations - the contribution of proteomics for the understanding of the underlying myopathology. J Neuromuscul Dis. 2025.12 (2)271-278 PMID:40033989
Malaichamy, S, Idoux, R, Polavarapu, K, Šikić, K, Holla, E, Thompson, R et al.. Dominant rhabdomyolysis linked to a recurrent ATP2A2 variant reducing SERCA2 function in muscle. Brain. 2025. PMID:39970126
Della Marina, A, Koutsoulidou, A, Natera-de Benito, D, Tykocinski, LO, Tomazou, M, Georgiou, K et al.. Blood biomarker fingerprints in a cohort of patients with CHRNE-related congenital myasthenic syndrome. Acta Neuropathol Commun. 2025.13 (1)29 PMID:39948634
Pauper, M, Hentschel, A, Tiburcy, M, Beltran, S, Ruck, T, Schara-Schmidt, U et al.. Proteomic Profiling Towards a Better Understanding of Genetic Based Muscular Diseases: The Current Picture and a Look to the Future. Biomolecules. 2025.15 (1) PMID:39858524
Neuhoff, K, Kilicarslan, OA, Preuße, C, Zaum, AK, Kölbel, H, Lochmüller, H et al.. Expanding the Molecular Genetic Landscape of Dystrophinopathies and Associated Phenotypes. Biomedicines. 2024.12 (12) PMID:39767645
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