Andreas Roos

Adjunct Professor, University of Ottawa

Scientific Officer, Department of Neuropediatrics, University Hospital Essen

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Andreas completed his PhD in 2009 with Professor Jan Senderek in the Neurogenetics group of the Institute of Human Genetics of RWTH-Aachen University in Germany, where his thesis focused on the elucidation of molecular and biochemical mechanisms in autosomal recessive Charcot-Marie-Tooth neuropathies. Following a postdoc in the Institute of Molecular Biology and Medical Biochemistry at the University of Saarland, he became a junior group leader at the Institute of Neuropathology at RWTH-Aachen University. Subsequently, he took on the role of group lead of the Tissue Omics group at the Leibniz Institute of Analytical Science (ISAS) in Dortmund, focusing on applied proteomics toward a better understanding of the molecular genesis of neuromuscular diseases. In 2015 he moved to Newcastle upon Tyne (UK) as Scientific Officer in the John Walton Muscular Dystrophy Research Centre under Professor Hanns Lochmüller. After moving to Essen in Germany in 2018 to become Scientific Officer in the  University Hospital Essen’s Department of Neuropediatrics, together with Prof. Ulrike Schara he was awarded a 2.9M Euro grant from the European Regional Development Fund for NMD-GPS, a major interdisciplinary multi-omics project aiming to improve the diagnostic management of patients with neuromuscular diseases as well as to group these diseases according to their underlying pathomechanisms.

In 2019 Andreas was awarded an adjunct professorship at the University of Ottawa, where he will be an external/visiting member of the Lochmüller Lab team, teaching applied proteomics in the context of neuromuscular diseases, co-supervising students and continuing his many close scientific collaborations with the group.

Dr. Andreas Roos

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Recent publications

Snijders Blok, L, Verseput, J, Rots, D, Venselaar, H, Innes, AM, Stumpel, C et al.. A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder. HGG Adv. 2023.4 (1)100157 PMID:36408368

Forsting, J, Rohm, M, Froeling, M, Güttsches, AK, Südkamp, N, Roos, A et al.. Quantitative muscle MRI captures early muscle degeneration in calpainopathy. Sci Rep. 2022.12 (1)19676 PMID:36385624

Nelke, C, Pawlitzki, M, Schroeter, CB, Huntemann, N, Räuber, S, Dobelmann, V et al.. High-Dimensional Cytometry Dissects Immunological Fingerprints of Idiopathic Inflammatory Myopathies. Cells. 2022.11 (20) PMID:36291195

Guettsches, AK, Meyer, N, Zahedi, RP, Evangelista, T, Muentefering, T, Ruck, T et al.. FYCO1 Increase and Effect of Arimoclomol-Treatment in Human VCP-Pathology. Biomedicines. 2022.10 (10) PMID:36289705

Kleefeld, F, Uruha, A, Schänzer, A, Nishimura, A, Roos, A, Schneider, U et al.. Morphologic and Molecular Patterns of Polymyositis With Mitochondrial Pathology and Inclusion Body Myositis. Neurology. 2022.99 (20)e2212-e2222 PMID:36195449

Christiansen, J, Güttsches, AK, Schara-Schmidt, U, Vorgerd, M, Heute, C, Preusse, C et al.. ANO5-related muscle diseases: From clinics and genetics to pathology and research strategies. Genes Dis. 2022.9 (6)1506-1520 PMID:36157496

Preusse, C, Marteau, T, Fischer, N, Hentschel, A, Sickmann, A, Lang, S et al.. Endoplasmic reticulum-stress and unfolded protein response-activation in immune-mediated necrotizing myopathy. Brain Pathol. 2022.32 (6)e13084 PMID:35703068

Gangfuß, A, Hentschel, A, Heil, L, Gonzalez, M, Schönecker, A, Depienne, C et al.. Proteomic and morphological insights and clinical presentation of two young patients with novel mutations of BVES (POPDC1). Mol Genet Metab. 2022.136 (3)226-237 PMID:35660068

Kölbel, H, Kraft, F, Hentschel, A, Czech, A, Gangfuss, A, Mohassel, P et al.. New Insights into the Neuromyogenic Spectrum of a Gain of Function Mutation in SPTLC1. Genes (Basel). 2022.13 (5) PMID:35627278

Preuße, C, Paesler, B, Nelke, C, Cengiz, D, Müntefering, T, Roos, A et al.. Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis. Acta Neuropathol. 2022.144 (2)353-372 PMID:35612662

Jackson, J, Wischhof, L, Scifo, E, Pellizzer, A, Wang, Y, Piazzesi, A et al.. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Mol Metab. 2022.61 101503 PMID:35452878

Koutsoulidou, A, Koutalianos, D, Georgiou, K, Kakouri, AC, Oulas, A, Tomazou, M et al.. Serum miRNAs as biomarkers for the rare types of muscular dystrophy. Neuromuscul Disord. 2022.32 (4)332-346 PMID:35393236

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