Neuromuscular junction and animal models

Lochmüller Lab

Hanns Lochmüller and team - research and clinical activities

Anu Mary Varghese

Postdoctoral Fellow

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Anu recently joined Lochmuller Lab as a postdoctoral fellow. She had completed her PhD at National Institute of Mental Health and Neuro Sciences (NIMHANS), India in 2015 under Prof. T R Raju. Her PhD work led to identification of Chitotriosidase as biomarker of Amyotrophic Lateral Sclerosis (ALS). She expanded on her findings by validating the biomarkers and characterised them using in-vivo and in-vitro models of sporadic ALS as postdoctoral fellow from 2016 – 2019.

Anu is looking forward to start her work on gene therapy for Congenital myasthenic syndromes (CMS) and on biomarkers for myotonic dystrophy type 1 (DM1).

Anu Mary Varghese

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Recent publications

Varghese, AM, Ghosh, M, Bhagat, SK, Vijayalakshmi, K, Preethish-Kumar, V, Vengalil, S et al.. Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation. J Neuroinflammation. 2020.17 (1)232 PMID:32762702

Shruthi, S, Sumitha, R, Varghese, AM, Ashok, S, Chandrasekhar Sagar, BK, Sathyaprabha, TN et al.. Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line. Neurodegener Dis. 2017.17 (1)44-58 PMID:27617773

Sharma, A, Varghese, AM, Vijaylakshmi, K, Sumitha, R, Prasanna, VK, Shruthi, S et al.. Cerebrospinal Fluid from Sporadic Amyotrophic Lateral Sclerosis Patients Induces Mitochondrial and Lysosomal Dysfunction. Neurochem Res. 2016.41 (5)965-84 PMID:26646005

Vijayalakshmi, K, Ostwal, P, Sumitha, R, Shruthi, S, Varghese, AM, Mishra, P et al.. Role of VEGF and VEGFR2 Receptor in Reversal of ALS-CSF Induced Degeneration of NSC-34 Motor Neuron Cell Line. Mol Neurobiol. 2015.51 (3)995-1007 PMID:24880751

Varghese, AM, Sharma, A, Mishra, P, Vijayalakshmi, K, Harsha, HC, Sathyaprabha, TN et al.. Chitotriosidase - a putative biomarker for sporadic amyotrophic lateral sclerosis. Clin Proteomics. 2013.10 (1)19 PMID:24295388

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