Anu Mary Varghese

Postdoctoral Fellow

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Anu recently joined Lochmuller Lab as a postdoctoral fellow. She had completed her PhD at National Institute of Mental Health and Neuro Sciences (NIMHANS), India in 2015 under Prof. T R Raju. Her PhD work led to identification of Chitotriosidase as biomarker of Amyotrophic Lateral Sclerosis (ALS). She expanded on her findings by validating the biomarkers and characterised them using in-vivo and in-vitro models of sporadic ALS as postdoctoral fellow from 2016 – 2019.

Anu is looking forward to start her work on gene therapy for Congenital myasthenic syndromes (CMS) and on biomarkers for myotonic dystrophy type 1 (DM1).

Anu Mary Varghese

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Recent publications

Savant, R, Pradhan, RK, Bhagat, S, Mythri, RB, Varghese, AM, Vengalil, S et al.. Enhanced Levels of Fractalkine and HSP60 in Cerebrospinal Fluid of Sporadic Amyotrophic Lateral Sclerosis Patients. Int J Neurosci. 2024. 1-14 PMID:38625841

Ramya, V, Sarkar, N, Bhagat, S, Pradhan, RK, Varghese, AM, Nalini, A et al.. Oligodendroglia Confer Neuroprotection to NSC-34 Motor Neuronal Cells Against the Toxic Insults of Cerebrospinal Fluid from Sporadic Amyotrophic Lateral Sclerosis Patients. Mol Neurobiol. 2023.60 (9)4855-4871 PMID:37184766

van Cruchten, RTP, van As, D, Glennon, JC, van Engelen, BGM, 't Hoen, PAC, OPTIMISTIC consortium et al.. Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood. BMC Med. 2022.20 (1)395 PMID:36352383

Sukumaran, SK, Paul, P, Guttal, V, Holla, B, Vemula, A, Bhatt, H et al.. Abnormalities in the migration of neural precursor cells in familial bipolar disorder. Dis Model Mech. 2022.15 (10) PMID:36239094

Varghese, AM, Ghosh, M, Bhagat, SK, Vijayalakshmi, K, Preethish-Kumar, V, Vengalil, S et al.. Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation. J Neuroinflammation. 2020.17 (1)232 PMID:32762702

Shruthi, S, Sumitha, R, Varghese, AM, Ashok, S, Chandrasekhar Sagar, BK, Sathyaprabha, TN et al.. Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line. Neurodegener Dis. 2017.17 (1)44-58 PMID:27617773

Sharma, A, Varghese, AM, Vijaylakshmi, K, Sumitha, R, Prasanna, VK, Shruthi, S et al.. Cerebrospinal Fluid from Sporadic Amyotrophic Lateral Sclerosis Patients Induces Mitochondrial and Lysosomal Dysfunction. Neurochem Res. 2016.41 (5)965-84 PMID:26646005

Vijayalakshmi, K, Ostwal, P, Sumitha, R, Shruthi, S, Varghese, AM, Mishra, P et al.. Role of VEGF and VEGFR2 Receptor in Reversal of ALS-CSF Induced Degeneration of NSC-34 Motor Neuron Cell Line. Mol Neurobiol. 2015.51 (3)995-1007 PMID:24880751

Varghese, AM, Sharma, A, Mishra, P, Vijayalakshmi, K, Harsha, HC, Sathyaprabha, TN et al.. Chitotriosidase - a putative biomarker for sporadic amyotrophic lateral sclerosis. Clin Proteomics. 2013.10 (1)19 PMID:24295388

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