Aoife Reilly

Research Coordinator

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Aoife is a Research Coordinator with the Lochmüller research group. She assists with lab management and coordinates the administrative operations of the University of Ottawa’s Centre for Neuromuscular Disease (CNMD), co-led by Dr. Lochmüller and Dr. Mireille Khacho. Aoife earned her PhD in Cellular and Molecular Medicine from the University of Ottawa, where her research focused on understanding the contributions of the peripheral organs to Spinal Muscular Atrophy pathogenesis.

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Recent publications

Reilly, A, Beauvais, A, Al-Aarg, M, Yaworski, R, Sutton, ER, Thebault, S et al.. Peripheral defects precede neuromuscular pathology in the Smn2B/- mouse model of spinal muscular atrophy. J Neuromuscul Dis. 2024.11 (6)1200-1210 PMID:39973467

Sutton, ER, Beauvais, A, Yaworski, R, De Repentigny, Y, Reilly, A, Alves de Almeida, MM et al.. Liver SMN restoration rescues the Smn2B/- mouse model of spinal muscular atrophy. EBioMedicine. 2024.110 105444 PMID:39515026

Reilly, A, Yaworski, R, Beauvais, A, Schneider, BL, Kothary, R. Long term peripheral AAV9-SMN gene therapy promotes survival in a mouse model of spinal muscular atrophy. Hum Mol Genet. 2024.33 (6)510-519 PMID:38073249

Alves, CRR, Ha, LL, Yaworski, R, Sutton, ER, Lazzarotto, CR, Christie, KA et al.. Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy. Nat Biomed Eng. 2024.8 (2)118-131 PMID:38057426

Alves, CRR, Ha, LL, Yaworski, R, Lazzarotto, CR, Christie, KA, Reilly, A et al.. Base editing as a genetic treatment for spinal muscular atrophy. bioRxiv. 2023. PMID:36711797

Reilly, A, Chehade, L, Kothary, R. Curing SMA: Are we there yet?. Gene Ther. 2023.30 (1-2)8-17 PMID:35614235

Reilly, A, Deguise, MO, Beauvais, A, Yaworski, R, Thebault, S, Tessier, DR et al.. Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy. Gene Ther. 2022.29 (9)544-554 PMID:35462564

Deguise, MO, De Repentigny, Y, Tierney, A, Beauvais, A, Michaud, J, Chehade, L et al.. Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy. EBioMedicine. 2020.55 102750 PMID:32339936

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