Haley Geertsma

Postdoctoral Research Fellow

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Haley Geertsma completed her PhD in 2024 under the supervision of Dr. Maxime Rousseaux from the University of Ottawa. Her thesis aimed to investigate the consequences of the chronic nuclear accumulation of alpha-synuclein in a mouse model of Parkinson’s disease. Her research involved mapping the cell-specific topography of alpha-synuclein, characterizing a novel mouse model, and using TurboID to identify the nuclear alpha-synuclein-specific interactome.

Haley’s research interests are centered around understanding the molecular mechanism of disease. Haley has joined the Lochmüller lab as a postdoctoral fellow to use patient-derived stem cells to discover new drug therapies for myotonic dystrophy.

Haley Geertsma

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Recent publications

Parmasad, JA, Ricke, KM, Nguyen, B, Stykel, MG, Buchner-Duby, B, Bruce, A et al.. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Cell Death Dis. 2024.15 (4)246 PMID:38575601

Geertsma, HM, Fisk, ZA, Sauline, L, Prigent, A, Kurgat, K, Callaghan, SM et al.. A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs. NPJ Parkinsons Dis. 2024.10 (1)65 PMID:38504090

Suk, TR, Nguyen, TT, Fisk, ZA, Mitkovski, M, Geertsma, HM, Parmasad, JA et al.. Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain. iScience. 2023.26 (4)106350 PMID:37009224

Geertsma, HM, Ricke, KM, Rousseaux, MWC. Assessment of Dopaminergic Neurodegeneration in Mice. Methods Mol Biol. 2022.2515 151-169 PMID:35776351

Geertsma, HM, Suk, TR, Ricke, KM, Horsthuis, K, Parmasad, JA, Fisk, ZA et al.. Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation. Hum Mol Genet. 2022.31 (21)3613-3628 PMID:35179202

Geertsma, HM, Rousseaux, MWC. Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease. EBioMedicine. 2020.52 102627 PMID:31981980

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