Jian-Jun Jia

Research Assistant, CHEO Research Institute

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Jian-jun finished his MSc in microbiology (Virology) at the University of Montreal, Faculty of Veterinary Medicine in 2009. Following this he joined the lab of Professor Earl Brown as a research assistant at the University of Ottawa. In 2014, he started working in the lab of Dr Tommy Alain of the CHEO Research Institute. Having worked in the areas of influenza virus revolution, cancer, and translation he has built up many skills in virology and molecular biology related areas, including RNA, gene cloning, gene expression, ribosome profiling, tissues/cell culture, gene mutagenesis, protein purification and quantification, real-time PCR and digital PCR. In 2019 he joined the lab of Professor Hanns Lochmüller where he put his molecular biology and tissue culturing techniques to use for research into neuromuscular diseases.

Jian-Jun Jia

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Recent publications

Jia, JJ, Lahr, RM, Solgaard, MT, Moraes, BJ, Pointet, R, Yang, AD et al.. mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. Nucleic Acids Res. 2021.49 (6)3461-3489 PMID:33398329

D'Aoust, PM, Mercier, E, Montpetit, D, Jia, JJ, Alexandrov, I, Neault, N et al.. Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence. Water Res. 2021.188 116560 PMID:33137526

Pearl, D, Katsumura, S, Amiri, M, Tabatabaei, N, Zhang, X, Vinette, V et al.. 4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response. J Immunol. 2020.204 (9)2392-2400 PMID:32213561

Hoang, HD, Graber, TE, Jia, JJ, Vaidya, N, Gilchrist, VH, Xiang, X et al.. Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection. Cell Rep. 2019.29 (12)4010-4023.e5 PMID:31851930

Zakaria, C, Sean, P, Hoang, HD, Leroux, LP, Watson, M, Workenhe, ST et al.. Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. PLoS Pathog. 2018.14 (8)e1007264 PMID:30138450

Lahr, RM, Fonseca, BD, Ciotti, GE, Al-Ashtal, HA, Jia, JJ, Niklaus, MR et al.. La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife. 2017.6 PMID:28379136

Fonseca, BD, Zakaria, C, Jia, JJ, Graber, TE, Svitkin, Y, Tahmasebi, S et al.. La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem. 2015.290 (26)15996-6020 PMID:25940091

Forbes, N, Selman, M, Pelchat, M, Jia, JJ, Stintzi, A, Brown, EG et al.. Identification of adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression. PLoS One. 2013.8 (12)e84673 PMID:24391972

Selman, M, Dankar, SK, Forbes, NE, Jia, JJ, Brown, EG. Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing. Emerg Microbes Infect. 2012.1 (11)e42 PMID:26038410

Forbes, NE, Ping, J, Dankar, SK, Jia, JJ, Selman, M, Keleta, L et al.. Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse. PLoS One. 2012.7 (2)e31839 PMID:22363747

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