Kiran Polavarapu

Postdoctoral Fellow

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Dr. Kiran Polavarapu completed his PhD in 2019 at the National Institute of Mental Health and Neurosciences (NIMHANS) in India. He is an M.B.B.S (Bachelor of Medicine and Bachelor of Surgery) graduate who shifted his focus to research in neuromuscular disorders and neurogenetics. His PhD work involved developing next generation sequencing (NGS)-based tests for detection of both copy number variations and point mutations in Duchenne Muscular Dystrophy. He further worked on analysing NGS data and genotype-phenotype correlations of various inherited neuromuscular disorders in India including Limb-Girgle Muscular Dystrophy, congenital myopathies, hereditary neuropathies, and Congenital Myasthenic Syndrome. He was part of a monthly neuromuscular disease specialty clinic run by Professor Atchayaram Nalini (neuromuscular specialist) at NIMHANS and was involved in clinical evaluation and genetic counselling of patients with inherited neuromuscular disorders. His research interest is in primary muscle disorders and neuromuscular genetics. He recently joined the Lochmüller Lab as a postdoctoral fellow and is looking forward to continuing research in neuromuscular genetics and Congenital Myathenic Syndrome.

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Recent publications

Varghese, AM, Ghosh, M, Bhagat, SK, Vijayalakshmi, K, Preethish-Kumar, V, Vengalil, S et al.. Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation. J Neuroinflammation. 2020.17 (1)232 PMID:32762702

Uemura, M, Nozaki, H, Kato, T, Koyama, A, Sakai, N, Ando, S et al.. HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature. Front Neurol. 2020.11 545 PMID:32719647

Lithin, Z, Thomas, PT, Warrier, GM, Bhaskar, A, Nashi, S, Vengalil, S et al.. Palliative Care Needs and Care Giver Burden in Neurodegenerative Diseases: A Cross Sectional Study. Ann Indian Acad Neurol. .23 (3)313-317 PMID:32606518

Vengalil, S, Lavania, M, Singh, I, Nashi, S, Preethish-Kumar, V, Polavarapu, K et al.. Appropriately Selected Nerve in Suspected Leprous Neuropathy Yields High Positive Results for Mycobacterium leprae DNA by Polymerase Chain Reaction Method. Am J Trop Med Hyg. 2020.103 (1)209-213 PMID:32285768

Warrier, MG, Sadasivan, A, Polavarapu, K, Kumar, VP, Mahajan, NP, Reddy, CPC et al.. Lived Experience of Spouses of Persons with Motor Neuron Disease: Preliminary Findings through Interpretative Phenomenological Analysis. Indian J Palliat Care. .26 (1)60-65 PMID:32132786

Shamim, U, Ambawat, S, Singh, J, Thomas, A, Pradeep-Chandra-Reddy, C, Suroliya, V et al.. C9orf72 hexanucleotide repeat expansion in Indian patients with ALS: a common founder and its geographical predilection. Neurobiol Aging. 2020.88 156.e1-156.e9 PMID:32035847

Mahajan, NP, Lavania, M, Singh, I, Nashi, S, Preethish-Kumar, V, Vengalil, S et al.. Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India. Am J Trop Med Hyg. 2020.102 (3)547-552 PMID:31933458

Gomez, G, Khanna, M, Gupta, A, Nalini, A, Thennarasu, K, Nashi, S et al.. GNE myopathy - A cross-sectional study on spatio-temporal gait characteristics. Neuromuscul Disord. 2019.29 (12)961-967 PMID:31787465

Sunitha, B, Kumar, M, Gowthami, N, Unni, S, Gayathri, N, Keshava Prasad, TS et al.. Human muscle pathology is associated with altered phosphoprotein profile of mitochondrial proteins in the skeletal muscle. J Proteomics. 2020.211 103556 PMID:31655151

Balaraju, S, Töpf, A, McMacken, G, Kumar, VP, Pechmann, A, Roper, H et al.. Congenital myasthenic syndrome with mild intellectual disability caused by a recurrent SLC25A1 variant. Eur J Hum Genet. 2020.28 (3)373-377 PMID:31527857

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