Marc-Olivier Deguise

Pediatric Resident, CHEO

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Marc-Olivier Deguise is currently a pediatric resident physician at Children’s Hospital of Eastern Ontario and has been involved with the SMA community through a research lens for the past eight years. He obtained his MD/PhD combined degree at the University of Ottawa under the supervision of Dr. Rashmi Kothary. During his PhD in Dr. Kothary’s laboratory, he significantly developed the idea of SMA as a systemic disease rather than merely a motor neuron disease. He either led or contributed to the identification of muscle defects, immune system dysfunction, defective amino acid and fatty acid metabolism in SMA as well as the development of a new type IV-like mild model of SMA mice. His latest work focuses on satellite cell impairments, metabolic defects in SMA and translation of basic SMA research in the patient population. The breadth of his work was recognized by multiple accolades, most notably the Canadian Medical Hall of Fame Award for medical student (2018) and the Dr. Ronald G. Worton Researcher in Training Award of the Ottawa Hospital (2017), amongst others.

Marc-Olivier recently joined Dr. Lochmüller’s Lab to contribute to the clinical research aspect of the research program.

Marc-Olivier Deguise

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Recent publications

Chehade, L, Deguise, MO, De Repentigny, Y, Yaworski, R, Beauvais, A, Gagnon, S et al.. Suppression of the necroptotic cell death pathways improves survival in Smn 2B/- mice. Front Cell Neurosci. 2022.16 972029 PMID:35990890

Reilly, A, Deguise, MO, Beauvais, A, Yaworski, R, Thebault, S, Tessier, DR et al.. Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy. Gene Ther. 2022.29 (9)544-554 PMID:35462564

Khayrullina, G, Alipio-Gloria, ZA, Deguise, MO, Gagnon, S, Chehade, L, Stinson, M et al.. Survival motor neuron protein deficiency alters microglia reactivity. Glia. 2022.70 (7)1337-1358 PMID:35373853

Niznick, N, Lun, R, Gotfrit, R, Deguise, MO, Ramsay, T, Blacquiere, D et al.. Resident Match During the COVID Pandemic: How have Neurology Programs Adapted? - A Survey. Can J Neurol Sci. 2022. 1-31 PMID:35189987

Deguise, MO, Chehade, L, Kothary, R. Metabolic Dysfunction in Spinal Muscular Atrophy. Int J Mol Sci. 2021.22 (11) PMID:34072857

Deguise, MO, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L et al.. SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease. Cell Mol Gastroenterol Hepatol. 2021.12 (1)354-377.e3 PMID:33545428

Deguise, MO, De Repentigny, Y, Tierney, A, Beauvais, A, Michaud, J, Chehade, L et al.. Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy. EBioMedicine. 2020.55 102750 PMID:32339936

Deguise, MO, Beauvais, A, Schneider, BL, Kothary, R. Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy. J Neuromuscul Dis. 2020.7 (3)315-322 PMID:32333548

Deguise, MO, Chehade, L, Tierney, A, Beauvais, A, Kothary, R. Low fat diets increase survival of a mouse model of spinal muscular atrophy. Ann Clin Transl Neurol. 2019.6 (11)2340-2346 PMID:31608604

Nery, FC, Siranosian, JJ, Rosales, I, Deguise, MO, Sharma, A, Muhtaseb, AW et al.. Impaired kidney structure and function in spinal muscular atrophy. Neurol Genet. 2019.5 (5)e353 PMID:31517062

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