Stephen Holland

PhD Student

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Stephen has recently graduated with an MSc degree from the University of Ottawa, where he worked in Dr. Kyle Cowan’s lab at the Children’s Hospital of Eastern Ontario studying the role of post-translational modifications affecting pannexin 1 protein channels. He previously worked with Dr. William Willmore at Carleton University, where he studied transcription factor NFE2L1 turnover in different cell models and volunteered his time with Dr. Sherri Katz by using clinical epidemiology to decipher the clinical predictors of non-adherence to PAP therapy in children.

Stephen has enrolled as a PhD student in the uOttawa Cellular and Molecular Medicine program under the supervision of Dr. Lochmüller, where he is excited to begin researching the role of glycosylation at the neuromuscular junction and examining glycosylation gene deficiencies in CMS.

 

Stephen-Holland

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ResearchGate profile

Recent publications

Holland, SH, Carmona-Martinez, R, O'Connor, K, O'Neil, D, Roos, A, Spendiff, S et al.. A Deficiency in Glutamine-Fructose-6-Phosphate Transaminase 1 (Gfpt1) in Skeletal Muscle Results in Reduced Glycosylation of the Delta Subunit of the Nicotinic Acetylcholine Receptor (AChRδ). Biomolecules. 2024.14 (10) PMID:39456185

Pugliese, A, Holland, SH, Rodolico, C, Lochmüller, H, Spendiff, S. Presynaptic Congenital Myasthenic Syndromes: Understanding Clinical Phenotypes through In vivo Models. J Neuromuscul Dis. 2023.10 (5)731-759 PMID:37212067

Langlois, S, St-Pierre, ME, Holland, SH, Xiang, X, Freeman, E, Mohamed, H et al.. Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma. J Cancer. 2023.14 (5)689-706 PMID:37056395

Laframboise, SJ, Bailey, T, Dang, AT, Rose, M, Zhou, Z, Berg, MD et al.. Analysis of financial challenges faced by graduate students in Canada. Biochem Cell Biol. 2023.101 (4)326-360 PMID:37040564

Blinder, H, Momoli, F, Holland, SH, Blinder, A, Radhakrishnan, D, Katz, SL et al.. Clinical predictors of nonadherence to positive airway pressure therapy in children: a retrospective cohort study. J Clin Sleep Med. 2021.17 (6)1183-1192 PMID:33590820

Langlois S, St-Pierre ME, Holland SH, Xiang X, Freeman E, Mohamed H, Cem Dural A, Hammad A, Karami S, van de Panne C, Cowan K. Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma. J. Cancer 2023; 14(5): 689-706. doi:10.7150/jca.79552

Holland, SH. Regulation of Neuroblastoma Malignant Properties by Pannexin 1 Channels: Role of Post-Translational Modifications and Mutations. uOttawa Master's Degree Thesis, 2021

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